CSS is just for separating how content looks from how it's structured. You can use it with XSLT (XSLT generates the structured XHTML in the server, and the client retrieves the generated XHTML and styles it with the CSS).
I've tried using CSS with Adobe GoLive, and I didn't like it (tools were a bit rough), but that was an older version of GoLive. I do all my HTML editing by hand.
I've got to get my hands on a copy of that book. Time to hit up Amazon.com. I browsed through that book at a borders in Hawaii. Excellent book. Excellent examples! Eric Meyer is the man as far as CSS is concerned.
The book is published by New Riders, right? Pretty much anything published by them is read-worthy.